Combination of prokinetics with PPI treatment is more effective than PPI alone in ... treatments, including histamine H2 receptor antagonists, prokinetics, alginate, ...HOMEAbouttheJournalArchivesForAuthorsForReviewersSubscriptionRequestPermissionTitleAuthorKeyword:::Volume:::Vol.27Vol.26Vol.25Vol.24Vol.23Vol.22Vol.21Vol.20Vol.19Vol.18Vol.17Vol.16Vol.15Vol.14Vol.13Vol.12Vol.11Vol.10Vol.9Vol.8Vol.7Vol.6Vol.5Vol.4Vol.3Vol.2Vol.1:::Issue:::No.4No.3No.2No.1Archives  |  Top10DOIsJNeurogastroenterolMotil2021;27(2):165-175  https://doi.org/10.5056/jnm20161ASystematicReviewandMeta-analysisofRandomizedControlTrials:CombinationTreatmentWithProtonPumpInhibitorPlusProkineticforGastroesophagealRefluxDiseaseDaHyunJung,1ChealWungHuh,2SangKilLee,1*JunChulPark,1SungKwanShin,1andYongChanLee11DepartmentofInternalMedicine,SeveranceHospital,YonseiUniversityCollegeofMedicine,Seoul,Korea;and2DepartmentofInternalMedicine,YonginSeveranceHospital,YonseiUniversityCollegeofMedicine,Seoul,KoreaCorrespondenceto:SangKilLee,MD,PhDDepartmentofInternalMedicine,YonseiUniversityCollegeofMedicine,50-1Yonsei-ro,Seodaemun-gu,Seoul03722,KoreaTel:+82-2-2228-1996,Fax:+82-2-393-6884,E-mail:sklee@yuhs.acDaHyunJungandChealWungHuhequallycontributedtothiswork.Received:July16,2020;Revised:December8,2020;Accepted:December28,2020;Publishedonline:April30,2021©TheKoreanSocietyofNeurogastroenterologyandMotility.Allrightsreserved.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionNon-CommercialLicense(http://creativecommons.org/licenses/by-nc/4.0)whichpermitsunrestrictednon-commercialuse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.OtherSectionsAbstractIntroductionMethodsResultsDiscussionSupplementaryMaterialsFinancialsupportConflictsofinterestAuthorcontributionsReferencesAbstractBackground/AimsProkineticscanbeusedfortreatingpatientswithgastroesophagealrefluxdisease(GERD),whoexhibitsuboptimalresponsetoprotonpumpinhibitor(PPI)treatment.Weconductedasystematic